Large-scale genomic rearrangements boost SCRaMbLE in Saccharomyces cerevisiae
Abstract Synthetic read more Chromosome Rearrangement and Modification by LoxP-mediated Evolution (SCRaMbLE) is a promising tool to study genomic rearrangements.However, the potential of SCRaMbLE to study genomic rearrangements is currently hindered, because a strain containing all 16 synthetic chromosomes is not yet available.Here, we construct Sp